Lidocaine and tissue penetration

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If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team. The dermis is similar to the epidermis, in the sense that it is mainly a water-rich area. This will slow down the rate of penetration, especially at the beginning will increase the lag time. They are more stable and may provide faster penetration to the stratum corneum than liposomes. A physiologically based pharmacokinetic model based on apparent tissue-tissue clearances and local blood flow to tissues is presented which adequately describes the concentration-time profiles of lidocaine in underlying tissues after dermal application. The Project envisages the development of a common methodology for the preparation, storage, dissemination and evaluation of scientific literature in electronic format.
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Iontophoretic transdermal delivery of salicylic acid and lidocaine to local subcutaneous structures. - PubMed - NCBI

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Lidocaine and Epinephrine

S E Cross Zhenyu Wu Michael Roberts. Masubuchi Y, Umeda S, Igarashi S, Fujita S, Narimatsu S, Suzuki T Participation of the CYP2D subfamily in lidocaine 3-hydroxylation and formation of a reactive metabolite covalently bound to liver microsomal protein in rats. More intense and longer duration of action than procaine.
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Lidocaine and tissue penetration
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